منابع مشابه
Humification of Pyrene in Contami- Nated Soil during Land Farming
252 Pyrene, a polycyclic aromatic hydrocarbon (PAH) compound present in contaminated soil at the Champion International Superfund site in Libby, Montana, a site presently undergoing land farming/preparedbed bioremediation, was evaluated with regard to incorporation into soil components (humification) in biologically active and poisoned treatments under varying environmental conditions including...
متن کاملPharmacokinetics of trimetrexate (NSC 352122) in monkeys.
The pharmacokinetics of trimetrexate was studied in Rhesus monkeys following i.v. bolus, continuous i.v. infusion, oral, and subcutaneous administration. Two methods were used to measure drug concentration in plasma, cerebrospinal fluid (CSF), and urine: the dihydrofolate reductase inhibition assay, and a reverse phase high-pressure liquid chromatography assay. The pharmacokinetic behavior of t...
متن کاملComparative Metabolism of Batracylin (NSC 320846) and N-acetylbatracylin (NSC 611001) Using Human, Dog, and Rat Preparations In Vitro.
BACKGROUND Batracylin is a heterocyclic arylamine topoisomerase inhibitor with preclinical anticancer activity. Marked species differences in sensitivity to the toxicity of batracylin were observed and attributed to differential formation of N-acetylbatracylin by N-acetyltransferase. A Phase I trial of batracylin in cancer patients with slow acetylator genotypes identified a dose-limiting toxic...
متن کاملSequential 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and 5-fluorouracil (NSC 19893) therapy of gastrointestinal cancer.
Thirty-six patients with advanced gastrointestinal carcinoma were treated sequentially with full therapeutic doses of l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea followed by 5-fluorouracil. 5-Fluorouracil could be safely administered at 6 weeks although patients still demonstrated peripheral hematological depression secondary to the earlier l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea therapy....
متن کاملNovel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.
Camptothecin (CPT) derivatives are effective anticancer drugs, especially against solid tumors. As CPTs are chemically unstable and have clinical limitations, we have synthesized indenoisoquinolines as novel topoisomerase I (Top1) inhibitors. We presently report two indenoisoquinoline derivatives, NSC 725776 and NSC 724998, which have been selected for therapeutic development. Both are potent T...
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ژورنال
عنوان ژورنال: South African Journal of Higher Education
سال: 2016
ISSN: 1753-5913
DOI: 10.20853/26-3-174